| Reaction Details |
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 | Report a problem with these data |
| Target | DNA topoisomerase 4 subunit B |
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| Ligand | BDBM50173878 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1580966 (CHEMBL3812634) |
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| IC50 | 746±n/a nM |
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| Citation |  Cross, JB; Zhang, J; Yang, Q; Mesleh, MF; Romero, JA; Wang, B; Bevan, D; Poutsiaka, KM; Epie, F; Moy, T; Daniel, A; Shotwell, J; Chamberlain, B; Carter, N; Andersen, O; Barker, J; Ryan, MD; Metcalf, CA; Silverman, J; Nguyen, K; Lippa, B; Dolle, RE Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design. ACS Med Chem Lett7:374-8 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA topoisomerase 4 subunit B |
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| Name: | DNA topoisomerase 4 subunit B |
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| Synonyms: | DNA topoisomerase 4 subunit B | DNA topoisomerase 4 subunit B (parE) | PARE_STAA8 | Topoisomerase IV subunit B | grlB | parE |
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| Type: | Enzyme |
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| Mol. Mass.: | 74365.92 |
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| Organism: | Staphylococcus aureus |
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| Description: | Q2FYS5 |
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| Residue: | 663 |
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| Sequence: | MNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEI
DVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGA
SVVNALSEWLEVEIHRDGNIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFKAS
TSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEVLH
DVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYAR
RINELKTKDKNLDGNDIREGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVADK
LPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQSKN
TEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHTI
GAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLY
KLEKGKGKTKRVEYAWTDEELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETRTL
IRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGMQEDQSILDNSEVQVLENDQFDE
EEI
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| BDBM50173878 |
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| n/a |
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| Name | BDBM50173878 |
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| Synonyms: | CHEMBL3809316 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13N5OS |
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| Mol. Mass. | 323.372 |
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| SMILES | CCn1c2[nH]nc(-c3cnc(s3)-c3cccnc3)c2ccc1=O |
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| Structure | 
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