| Reaction Details |
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 | Report a problem with these data |
| Target | DNA gyrase subunit B |
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| Ligand | BDBM50173889 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1580968 (CHEMBL3812636) |
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| IC50 | 4.0±n/a nM |
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| Citation |  Cross, JB; Zhang, J; Yang, Q; Mesleh, MF; Romero, JA; Wang, B; Bevan, D; Poutsiaka, KM; Epie, F; Moy, T; Daniel, A; Shotwell, J; Chamberlain, B; Carter, N; Andersen, O; Barker, J; Ryan, MD; Metcalf, CA; Silverman, J; Nguyen, K; Lippa, B; Dolle, RE Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design. ACS Med Chem Lett7:374-8 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA gyrase subunit B |
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| Name: | DNA gyrase subunit B |
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| Synonyms: | DNA gyrase | DNA gyrase subunit B (DNA gyraseB) | DNA gyrase subunit B (gyrB) | GYRB_STAAU | gyrB |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 72530.91 |
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| Organism: | Staphylococcus aureus |
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| Description: | n/a |
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| Residue: | 644 |
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| Sequence: | MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEAL
AGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVS
GGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKAD
GEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELL
NENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRAL
TRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVV
DKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLAD
CSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQ
MITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIA
QPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEH
RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
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| BDBM50173889 |
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| n/a |
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| Name | BDBM50173889 |
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| Synonyms: | CHEMBL3809400 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13N5OS |
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| Mol. Mass. | 335.383 |
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| SMILES | C=CCn1c2[nH]nc(-c3cnc(s3)-c3cccnc3)c2ccc1=O |
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| Structure | 
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