| Reaction Details |
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 | Report a problem with these data |
| Target | Branched-chain-amino-acid aminotransferase, mitochondrial |
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| Ligand | BDBM50173927 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1580973 (CHEMBL3812805) |
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| IC50 | 50±n/a nM |
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| Citation |  Deng, H; Zhou, J; Sundersingh, F; Messer, JA; Somers, DO; Ajakane, M; Arico-Muendel, CC; Beljean, A; Belyanskaya, SL; Bingham, R; Blazensky, E; Boullay, AB; Boursier, E; Chai, J; Carter, P; Chung, CW; Daugan, A; Ding, Y; Herry, K; Hobbs, C; Humphries, E; Kollmann, C; Nguyen, VL; Nicodeme, E; Smith, SE; Dodic, N; Ancellin, N Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm Inhibitors. ACS Med Chem Lett7:379-84 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Branched-chain-amino-acid aminotransferase, mitochondrial |
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| Name: | Branched-chain-amino-acid aminotransferase, mitochondrial |
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| Synonyms: | BCAT(m) | BCAT2 | BCAT2_HUMAN | BCATM | BCATM | BCT2 | Branched-chain-amino-acid aminotransferase, mitochondrial | ECA40 | PP18 | Placental protein 18 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44297.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109874 |
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| Residue: | 392 |
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| Sequence: | MAAAALGQIWARKLLSVPWLLCGPRRYASSSFKAADLQLEMTQKPHKKPGPGEPLVFGKT
FTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRP
WLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSL
GVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLV
QQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQS
LLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIP
TMENGPELILRFQKELKEIQYGIRAHEWMFPV
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| BDBM50173927 |
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| n/a |
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| Name | BDBM50173927 |
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| Synonyms: | CHEMBL3808902 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24BrN5O2S |
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| Mol. Mass. | 538.459 |
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| SMILES | CNC(=O)c1ccc2n([C@@H]3CCC[C@@H](C3)NC(=O)c3ccc(Br)s3)c(nc2c1)-c1ccccn1 |r| |
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| Structure | 
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