Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50174436 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1581001 (CHEMBL3813006) |
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Ki | 5.5±n/a nM |
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Citation | Kumar, S; Ceruso, M; Tuccinardi, T; Supuran, CT; Sharma, PK Pyrazolylbenzo[d]imidazoles as new potent and selective inhibitors of carbonic anhydrase isoforms hCA IX and XII. Bioorg Med Chem24:2907-2913 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50174436 |
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n/a |
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Name | BDBM50174436 |
Synonyms: | CHEMBL3809966 |
Type | Small organic molecule |
Emp. Form. | C23H19N5O3S |
Mol. Mass. | 445.494 |
SMILES | COc1ccc(cc1)-c1nn(cc1-c1nc2ccccc2[nH]1)-c1ccc(cc1)S(N)(=O)=O |
Structure |
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