| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM50175274 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1580653 (CHEMBL3810966) |
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| IC50 | 1200±n/a nM |
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| Citation |  Nakai, T; Perl, NR; Barden, TC; Carvalho, A; Fretzen, A; Germano, P; Im, GY; Jin, H; Kim, C; Lee, TW; Long, K; Moore, J; Rohde, JM; Sarno, R; Segal, C; Solberg, EO; Tobin, J; Zimmer, DP; Currie, MG Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans. ACS Med Chem Lett7:465-9 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42648.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41145 |
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| Residue: | 380 |
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| Sequence: | MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
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| BDBM50175274 |
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| n/a |
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| Name | BDBM50175274 |
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| Synonyms: | CHEMBL3809864 | US10189809, Compound I-97 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13FN6O |
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| Mol. Mass. | 336.3231 |
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| SMILES | Nc1ccnc(n1)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1 |
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| Structure | 
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