| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Synaptic vesicular amine transporter |
|---|
| Ligand | BDBM50175677 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1578947 (CHEMBL3810653) |
|---|
| Ki | 22±n/a nM |
|---|
| Citation |  Nickell, JR; Culver, JP; Janganati, V; Zheng, G; Dwoskin, LP; Crooks, PA 1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2. Bioorg Med Chem Lett26:2997-3000 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Synaptic vesicular amine transporter |
|---|
| Name: | Synaptic vesicular amine transporter |
|---|
| Synonyms: | Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 55689.58 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | Q01827 |
|---|
| Residue: | 515 |
|---|
| Sequence: | MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEI
QTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPS
EDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFS
SSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFG
SVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAG
SICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWL
CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYG
SVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEK
MAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
|
|
|
|---|
| BDBM50175677 |
|---|
| n/a |
|---|
| Name | BDBM50175677 |
|---|
| Synonyms: | CHEMBL3809594 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H30ClNO |
|---|
| Mol. Mass. | 359.933 |
|---|
| SMILES | Cl.COc1cccc(CCN2CCC(CCc3ccccc3)CC2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
