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TargetLiver X receptor (LXR alpha AND LXR beta)
LigandBDBM50177016
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1582623
Ki 1.000000±n/a nM
Citation Zheng YZhuang LFan KYTice CMZhao WDong CLotesta SDLeftheris KLindblom PRLiu ZShimada JNoto PBMeng SHardy AHoward LKrosky PGuo JLipinski KKandpal GBukhtiyarov YZhao YLala DVan Orden RZhou JChen GWu ZMcKeever BMMcGeehan GMGregg REClaremon DASingh SB Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) Agonist. J Med Chem 59:3264-71 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Liver X receptor (LXR alpha AND LXR beta)
Name:Liver X receptor (LXR alpha AND LXR beta)
Synonyms:Liver X receptor beta (NR1H2) | Liver X, LXR beta | Oxysterols receptor LXR-beta
Type:Protein
Mol. Mass.:50978.79
Organism:Homo sapiens (Human)
Description:P55055
Residue:460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDW
VIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGA
RRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQ
SQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKR
SFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQI
ALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMR
RLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRM
LMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
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  Blast E-value cutoff:
BDBM50177016
n/a
NameBDBM50177016
Synonyms:CHEMBL3814501
TypeSmall organic molecule
Emp. Form.C19H21ClF4N4O2S
Mol. Mass.480.907
SMILESCC(C)[C@@H]1CN(CCN1c1ncc(Cl)c(n1)C(F)(F)F)c1ccc(F)c(c1)S(C)(=O)=O |r|
Structure
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