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TargetPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
LigandBDBM50177715
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1581780 (CHEMBL3816306)
IC50 78±n/a nM
Citation Hatcher, JMWeisberg, ESim, TStone, RMLiu, SGriffin, JDGray, NS Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor. ACS Med Chem Lett7:476-81 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
Name:Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
Synonyms:PHKG | PHKG1 | PHKG1_HUMAN | Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform | Phosphorylase kinase | Phosphorylase kinase gamma subunit 1 | Phosphorylase kinase subunit gamma 1
Type:PROTEIN
Mol. Mass.:45025.22
Organism:Homo sapiens (Human)
Description:ChEMBL_774515
Residue:387
Sequence:
MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFS
PEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKV
TLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGER
LREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLR
MIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFS
PRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVK
KGQQQNRAALFENTPKAVLLSLAEEDY
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  Blast E-value cutoff:
BDBM50177715
n/a
NameBDBM50177715
Synonyms:CHEMBL3815054
TypeSmall organic molecule
Emp. Form.C26H24N6O
Mol. Mass.436.5084
SMILESCN(C)CCCn1cc(cn1)-c1ccc2C(=O)c3c([nH]c4cc(ccc34)-c3cn[nH]c3)-c2c1
Structure
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