Reaction Details |
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Target | Chromatin remodeling regulator CECR2 |
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Ligand | BDBM50178219 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1582087 (CHEMBL3817164) |
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IC50 | 7700±n/a nM |
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Citation | Taylor, AM; Côté, A; Hewitt, MC; Pastor, R; Leblanc, Y; Nasveschuk, CG; Romero, FA; Crawford, TD; Cantone, N; Jayaram, H; Setser, J; Murray, J; Beresini, MH; de Leon Boenig, G; Chen, Z; Conery, AR; Cummings, RT; Dakin, LA; Flynn, EM; Huang, OW; Kaufman, S; Keller, PJ; Kiefer, JR; Lai, T; Li, Y; Liao, J; Liu, W; Lu, H; Pardo, E; Tsui, V; Wang, J; Wang, Y; Xu, Z; Yan, F; Yu, D; Zawadzke, L; Zhu, X; Zhu, X; Sims, RJ; Cochran, AG; Bellon, S; Audia, JE; Magnuson, S; Albrecht, BK Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637). ACS Med Chem Lett7:531-6 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Chromatin remodeling regulator CECR2 |
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Name: | Chromatin remodeling regulator CECR2 |
Synonyms: | CECR2 | CECR2_HUMAN | Cat eye syndrome critical region protein 2 | KIAA1740 |
Type: | PROTEIN |
Mol. Mass.: | 164223.89 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_107999 |
Residue: | 1484 |
Sequence: | MCPEEGGAAGLGELRSWWEVPAIAHFCSLFRTAFRLPDFEIEELEAALHRDDVEFISDLI
ACLLQGCYQRRDITPQTFHSYLEDIINYRWELEEGKPNPLREASFQDLPLRTRVEILHRL
CDYRLDADDVFDLLKGLDADSLRVEPLGEDNSGALYWYFYGTRMYKEDPVQGKSNGELSL
SRESEGQKNVSSIPGKTGKRRGRPPKRKKLQEEILLSEKQEENSLASEPQTRHGSQGPGQ
GTWWLLCQTEEEWRQVTESFRERTSLRERQLYKLLSEDFLPEICNMIAQKGKRPQRTKAE
LHPRWMSDHLSIKPVKQEETPVLTRIEKQKRKEEEEERQILLAVQKKEQEQMLKEERKRE
LEEKVKAVEGMCSVRVVWRGACLSTSRPVDRAKRRKLREERAWLLAQGKELPPELSHLDP
NSPMREEKKTKDLFELDDDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMD
ISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCFHRAMMKHFP
GEDGDTDEEFWIREDEKREKRRSRAGRSGGSHVWTRSRDPEGSSRKQQPMENGGKSLPPT
RRAPSSGDDQSSSSTQPPREVGTSNGRGFSHPLHCGGTPSQAPFLNQMRPAVPGTFGPLR
GSDPATLYGSSGVPEPHPGEPVQQRQPFTMQPPVGINSLRGPRLGTPEEKQMCGGLTHLS
NMGPHPGSLQLGQISGPSQDGSMYAPAQFQPGFIPPRHGGAPARPPDFPESSEIPPSHMY
RSYKYLNRVHSAVWNGNHGATNQGPLGPDEKPHLGPGPSHQPRTLGHVMDSRVMRPPVPP
NQWTEQSGFLPHGVPSSGYMRPPCKSAGHRLQPPPVPAPSSLFGAPAQALRGVQGGDSMM
DSPEMIAMQQLSSRVCPPGVPYHPHQPAHPRLPGPFPQVAHPMSVTVSAPKPALGNPGRA
PENSEAQEPENDQAEPLPGLEEKPPGVGTSEGVYLTQLPHPTPPLQTDCTRQSSPQERET
VGPELKSSSSESADNCKAMKGKNPWPSDSSYPGPAAQGCVRDLSTVADRGALSENGVIGE
ASPCGSEGKGLGSSGSEKLLCPRGRTLQETMPCTGQNAATPPSTDPGLTGGTVSQFPPLY
MPGLEYPNSAAHYHISPGLQGVGPVMGGKSPASHPQHFPPRGFQSNHPHSGGFPRYRPPQ
GMRYSYHPPPQPSYHHYQRTPYYACPQSFSDWQRPLHPQGSPSGPPASQPPPPRSLFSDK
NAMASLQGCETLNAALTSPTRMDAVAAKVPNDGQNPGPEEEKLDESMERPESPKEFLDLD
NHNAATKRQSSLSASEYLYGTPPPLSSGMGFGSSAFPPHSVMLQTGPPYTPQRPASHFQP
RAYSSPVAALPPHHPGATQPNGLSQEGPIYRCQEEGLGHFQAVMMEQIGTRSGIRGPFQE
MYRPSGMQMHPVQSQASFPKTPTAATSQEEVPPHKPPTLPLDQS
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BDBM50178219 |
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n/a |
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Name | BDBM50178219 |
Synonyms: | CHEMBL3814752 |
Type | Small organic molecule |
Emp. Form. | C22H22N6O |
Mol. Mass. | 386.4497 |
SMILES | C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(-c5cnn(C)c5)c4c3)c2N1 |r| |
Structure |
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