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TargetNischarin
LigandBDBM50019646
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1583797 (CHEMBL3815884)
Ki 5.6±n/a nM
Citation Vucicevic, JSrdic-Rajic, TPieroni, MLaurila, JMPerovic, VTassini, SAzzali, ECostantino, GGlisic, SAgbaba, DScheinin, MNikolic, KRadi, MVeljkovic, N A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin. Bioorg Med Chem24:3174-83 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nischarin
Name:Nischarin
Synonyms:Imidazoline I1 | NISCH_RAT | Nisch | Nischarin
Type:Enzyme Catalytic Domain
Mol. Mass.:166460.59
Organism:RAT
Description:Q4G017
Residue:1502
Sequence:
MAAATLSFGPEREAEPAKEARVVGSELVDTYTVYVIQVTDGNHEWTIKHRYSDFHDLHEK
LVAERKIDKTLLPPKKIIGKNSRSLVEKREKDLEVYLQTLLKTFPDVAPRVLAHFLHFHL
YEINGVTAALAEELFEKGEQLLGAGEVFAIRPLQLYAITEQLQQGKPTCASGDAKTDLGH
ILDFTCRLKYLKVSGTEGPFGTSNIREQLLPFDLSIFKSLHQVEMSHCDAKHVRGLVTSK
PTLATMSVRFSAASMKEVLVPEASEFDEWEPEGTTLGGPVTAVIPTWQALTTLDLSHNSI
SEIDESVKLIPKIEYLDLSHNGVLVVDNLQHLYNLVHLDLSYNKLSSLEGVHTKLGNVKT
LNLAGNFLERLSGLHKLYSLVNLDLRDNRIEQLDEVKSIGNLPCLEHVALLNNPLSIIPD
YRTKVLSQFGERASEICLDDVATTEKELDTVEVLKAIQKAKDVKSKLSSTEKKVGEDFRL
PTAPCIRPSSSPPTAVPTSASLPQPILSNQGIMFVQEEALASSLSSTDSLPPDDRPIAQA
CSNSMGSLPTGQVAAEDLRDLPGAVGGVSPDHAEPEVQVVPGSGQIIFLPFTCIGYTATN
QDFIQRLSTLIRQAIERQLPAWIEAANQREEAHGEQGEEEEEEEEEDVAESRYFEMGPPD
AEEEEGSGQGEEDEEDEDEEAEEERLALEWALGADEDFLLEHIRILKVLWCFLIHVQGSI
RQFAACLVLTDFGIAVFEIPHQESRGSSQHILSSLRFVFCFPHGDLTEFGFLMPELCLVL
KVRHSENTLFIISDAANLHEFHADLRSCFAPQHMAMLCSPILYGSHTSLQEFLRQLLTFY
KVAGGSQERSQGCFPVYLVYSDKRMVQTAAGDYSGNIEWASCTLCSAVRRSCCAPSEAVK
SAAIPYWLLLTSQHLNVIKADFNPMPSRGTHNCRNRNSFKLSRVPLSTVLLDPTRSCTQP
RGAFADGHVLELLVGYRFVTAIFVLPHEKFHFLRVYNQLRASLKDLKTVVIAKNPSARPR
TQGPLAGGQPAKSRVSAEQRLQETPAEAPAPAPAAAESAAEAPAAAEASAPAGAPAPAGA
PAPAGAPAGAQAPAPAQAEVPAQYPSERLIQSTSEENQIPSHLPVCPSLQHIARLRGRAI
IDLFHSSIAEVENEELRHLLWSSVVFYQTPGLEVTACVLLSTKAVYFILHDGLRRYFSEP
LQDFWHQKNTDYNNSPFHISQCFVLKLSDLQSVNVGLFDQYFRLTGSSPTQVVTCLTRDS
YLTHCFLQHLMLVLSSLERTPSPEPIDKDFYSEFGDKNTGKMENYELIHSSRVKFTYPSE
EEVGDLTYVVAQKMADPAKNPALSILLYIQAFQVITPQLGRGRGPLRPKTLLLTSAEIFL
LDEDYIHYPLPEFAKEPPQRDRYRLDDGRRVRDLDRVLMGYNPYPQALTLVFDDTQGHDL
MGSVTLDHFGEMPGGPGRAGQGREVQWQVFVPSAESREKLISLLARQWEALCGRELPVEL
TG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50019646
n/a
NameBDBM50019646
Synonyms:2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline | 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole | CHEMBL17860 | lofexidine
TypeSmall organic molecule
Emp. Form.C11H12Cl2N2O
Mol. Mass.259.132
SMILESCC(Oc1c(Cl)cccc1Cl)C1=NCCN1 |t:12|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: