| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Monocarboxylate transporter 1 |
|---|
| Ligand | BDBM22000 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1584864 (CHEMBL3822206) |
|---|
| EC50 | 5.0±n/a nM |
|---|
| Citation |  Nair, RN; Mishra, JK; Li, F; Tortosa, M; Yang, C; Doherty, JR; Cameron, M; Cleveland, JL; Roush, WR; Bannister, TD Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitors. Medchemcomm7:900-905 (2016) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Monocarboxylate transporter 1 |
|---|
| Name: | Monocarboxylate transporter 1 |
|---|
| Synonyms: | MCT 1 | MCT1 | MOT1_HUMAN | Monocarboxylate transporter 1 | SLC16A1 | Solute carrier family 16 member 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 53956.64 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1451367 |
|---|
| Residue: | 500 |
|---|
| Sequence: | MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSW
ISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIG
GLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLI
LGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQ
EKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF
LLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYA
GFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYK
YTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKA
AESPDQKDTDGGPKEEESPV
|
|
|
|---|
| BDBM22000 |
|---|
| n/a |
|---|
| Name | BDBM22000 |
|---|
| Synonyms: | 7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methylpropyl)-6-(naphthalen-1-ylmethyl)-1H,2H,6H-pyrrolo[3,4-d]pyridazin-1-one | 7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methylpropyl)-6-(naphthalen-1-ylmethyl)-2,6-dihydro-1H-pyrrolo[3,4-d]pyridazin-1-one | Pyrrolo[3,4-d]pyridazin-1-one, 2 |
|---|
| Type | n/a |
|---|
| Emp. Form. | C25H29N3O2S |
|---|
| Mol. Mass. | 435.582 |
|---|
| SMILES | CC(C)Cc1nn(C)c(=O)c2c(SCCCO)n(Cc3cccc4ccccc34)cc12 |
|---|
| Structure | 
|
|---|
Search and Browse
