| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Potassium two pore domain channel subfamily K member 2 |
|---|
| Ligand | BDBM50088383 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1584412 (CHEMBL3819955) |
|---|
| IC50 | 430±n/a nM |
|---|
| Citation |  Vivier, D; Bennis, K; Lesage, F; Ducki, S Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target? J Med Chem59:5149-57 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Potassium two pore domain channel subfamily K member 2 |
|---|
| Name: | Potassium two pore domain channel subfamily K member 2 |
|---|
| Synonyms: | Potassium channel subfamily K member 2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 45443.30 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | ChEMBL_620769 |
|---|
| Residue: | 411 |
|---|
| Sequence: | MAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWKTVSTIFLVVVLYLII
GATVFKALEQPHEISQRTTIVIQKQTFISQHACVNSTELDELIQQIVAAINAGIIPLGNT
SNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQ
LGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAIIFKHIEGWSALD
AIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVIS
KKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSIKRKLSAELAGNHNQ
ELTPCRRTLSVNHLASERDVLPSLLKTESIYLNGLTPHCAGEEIAVIENIK
|
|
|
|---|
| BDBM50088383 |
|---|
| n/a |
|---|
| Name | BDBM50088383 |
|---|
| Synonyms: | Amlodipine | CHEBI:2668 | Norvasc |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H25ClN2O5 |
|---|
| Mol. Mass. | 408.876 |
|---|
| SMILES | CCOC(=O)C1=C(COCCN)NC(C)=C(C1c1ccccc1Cl)C(=O)OC |c:5,14| |
|---|
| Structure | 
|
|---|
Search and Browse
