Ki Summary

Reaction Details

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Target

Prolyl endopeptidase

Ligand

BDBM50051495

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1584425 (CHEMBL3819968)

0.060000±n/a nM

Citation

Mariaule, G; De Cesco, S; Airaghi, F; Kurian, J; Schiavini, P; Rocheleau, S; Huskic, I; Auclair, K; Mittermaier, A; Moitessier, N 3-Oxo-hexahydro-1H-isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase Inhibitors. J Med Chem59:4221-34 (2016) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Prolyl endopeptidase

Name:

Prolyl endopeptidase

Synonyms:

3.4.21.26 | PE | PPCE_PIG | PREP | Post-proline cleaving enzyme

Type:

n/a

Mol. Mass.:

80758.04

Organism:

Sus scrofa

Description:

n/a

Residue:

710

Sequence:

MLSFQYPDVYRDETAIQDYHGHKVCDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS
DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH
DGKGMFYNAYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL
SDDGRYVLLSIREGCDPVNRLWYCDLQQESNGITGILKWVKLIDNFEGEYDYVTNEGTVF
TFKTNRHSPNYRLINIDFTDPEESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNT
LQLHDLATGALLKIFPLEVGSVVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR
VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
TPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
GYTSPKRLTINGGSNGGLLVATCANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG
CSDSKQHFEWLIKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
GRSRKQNNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIDWIP

BDBM50051495

n/a

Name

BDBM50051495

Synonyms:

(S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carbonyl]-pyrrolidine-1-carboxylic acid benzylamide | (S)-N-benzyl-2-((S)-2-(2-hydroxyacetyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxamide | CHEMBL76578

Type

Small organic molecule

Emp. Form.

C19H25N3O4

Mol. Mass.

359.4195

SMILES

OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1

Structure