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TargetKelch-like ECH-associated protein 1
LigandBDBM50180854
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1584807 (CHEMBL3822030)
IC50>1000000±n/a nM
Citation Davies, TGWixted, WECoyle, JEGriffiths-Jones, CHearn, KMcMenamin, RNorton, DRich, SJRichardson, CSaxty, GWillems, HMWoolford, AJCottom, JEKou, JPYonchuk, JGFeldser, HGSanchez, YFoley, JPBolognese, BJLogan, GPodolin, PLYan, HCallahan, JFHeightman, TDKerns, JK Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. J Med Chem59:3991-4006 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kelch-like ECH-associated protein 1
Name:Kelch-like ECH-associated protein 1
Synonyms:Cytosolic inhibitor of Nrf2 | INRF2 | KEAP1 | KEAP1/Cullin-3/Microtubule-associated protein tau | KEAP1_HUMAN | KIAA0132 | KLHL19 | Kelch-like protein 19
Type:PROTEIN
Mol. Mass.:69664.53
Organism:Homo sapiens (Human)
Description:ChEMBL_107924
Residue:624
Sequence:
MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
RSGVGVAVTMEPCRKQIDQQNCTC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50180854
n/a
NameBDBM50180854
Synonyms:CHEMBL3819037
TypeSmall organic molecule
Emp. Form.C9H9ClO2
Mol. Mass.184.62
SMILESOC(=O)CCc1ccc(Cl)cc1
Structure
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