Reaction Details |
| Report a problem with these data |
Target | Kelch-like ECH-associated protein 1 |
---|
Ligand | BDBM50180854 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1584807 (CHEMBL3822030) |
---|
IC50 | >1000000±n/a nM |
---|
Citation | Davies, TG; Wixted, WE; Coyle, JE; Griffiths-Jones, C; Hearn, K; McMenamin, R; Norton, D; Rich, SJ; Richardson, C; Saxty, G; Willems, HM; Woolford, AJ; Cottom, JE; Kou, JP; Yonchuk, JG; Feldser, HG; Sanchez, Y; Foley, JP; Bolognese, BJ; Logan, G; Podolin, PL; Yan, H; Callahan, JF; Heightman, TD; Kerns, JK Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery. J Med Chem59:3991-4006 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Kelch-like ECH-associated protein 1 |
---|
Name: | Kelch-like ECH-associated protein 1 |
Synonyms: | Cytosolic inhibitor of Nrf2 | INRF2 | KEAP1 | KEAP1/Cullin-3/Microtubule-associated protein tau | KEAP1_HUMAN | KIAA0132 | KLHL19 | Kelch-like protein 19 |
Type: | PROTEIN |
Mol. Mass.: | 69664.53 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_107924 |
Residue: | 624 |
Sequence: | MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
RSGVGVAVTMEPCRKQIDQQNCTC
|
|
|
BDBM50180854 |
---|
n/a |
---|
Name | BDBM50180854 |
Synonyms: | CHEMBL3819037 |
Type | Small organic molecule |
Emp. Form. | C9H9ClO2 |
Mol. Mass. | 184.62 |
SMILES | OC(=O)CCc1ccc(Cl)cc1 |
Structure |
|