| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Proteinase-activated receptor 1 |
|---|
| Ligand | BDBM50181454 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1585283 (CHEMBL3821546) |
|---|
| IC50 | 130±n/a nM |
|---|
| Citation |  Eggert, E; Hillig, RC; Koehr, S; Stöckigt, D; Weiske, J; Barak, N; Mowat, J; Brumby, T; Christ, CD; Ter Laak, A; Lang, T; Fernandez-Montalvan, AE; Badock, V; Weinmann, H; Hartung, IV; Barsyte-Lovejoy, D; Szewczyk, M; Kennedy, S; Li, F; Vedadi, M; Brown, PJ; Santhakumar, V; Arrowsmith, CH; Stellfeld, T; Stresemann, C Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. J Med Chem59:4578-600 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Proteinase-activated receptor 1 |
|---|
| Name: | Proteinase-activated receptor 1 |
|---|
| Synonyms: | CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 47450.07 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25116 |
|---|
| Residue: | 425 |
|---|
| Sequence: | MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
|
|
|
|---|
| BDBM50181454 |
|---|
| n/a |
|---|
| Name | BDBM50181454 |
|---|
| Synonyms: | CHEMBL3818932 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H20Cl3N7O |
|---|
| Mol. Mass. | 492.789 |
|---|
| SMILES | CCN(C1CN(N=C1c1ccc(Cl)cc1)C(\Nc1ccc(Cl)c(Cl)c1)=N/C#N)C(=O)CN |c:6| |
|---|
| Structure | 
|
|---|
Search and Browse
