| Reaction Details |
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 | Report a problem with these data |
| Target | Proteinase-activated receptor 1 |
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| Ligand | BDBM50181510 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1585283 (CHEMBL3821546) |
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| IC50 | 80±n/a nM |
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| Citation |  Eggert, E; Hillig, RC; Koehr, S; Stöckigt, D; Weiske, J; Barak, N; Mowat, J; Brumby, T; Christ, CD; Ter Laak, A; Lang, T; Fernandez-Montalvan, AE; Badock, V; Weinmann, H; Hartung, IV; Barsyte-Lovejoy, D; Szewczyk, M; Kennedy, S; Li, F; Vedadi, M; Brown, PJ; Santhakumar, V; Arrowsmith, CH; Stellfeld, T; Stresemann, C Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. J Med Chem59:4578-600 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteinase-activated receptor 1 |
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| Name: | Proteinase-activated receptor 1 |
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| Synonyms: | CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1) |
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| Type: | Protein |
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| Mol. Mass.: | 47450.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25116 |
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| Residue: | 425 |
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| Sequence: | MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
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| BDBM50181510 |
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| n/a |
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| Name | BDBM50181510 |
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| Synonyms: | CHEMBL3818750 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H19ClF2N6O4 |
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| Mol. Mass. | 504.874 |
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| SMILES | CCN(C1CN(N=C1c1ccc(Cl)cc1)C(\Nc1ccc2OC(F)(F)Oc2c1)=N/C#N)C(=O)CO |c:6| |
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| Structure | 
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