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TargetSerine/threonine-protein kinase PAK 1
LigandBDBM50182402
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1584620 (CHEMBL3820948)
Ki 22±n/a nM
Citation Rudolph, JMurray, LJNdubaku, COO'Brien, TBlackwood, EWang, WAliagas, IGazzard, LCrawford, JJDrobnick, JLee, WZhao, XHoeflich, KPFavor, DADong, PZhang, HHeise, CEOh, AOng, CCLa, HChakravarty, PChan, CJakubiak, DEpler, JRamaswamy, SVega, RCain, GDiaz, DZhong, Y Chemically Diverse Group I p21-Activated Kinase (PAK) Inhibitors Impart Acute Cardiovascular Toxicity with a Narrow Therapeutic Window. J Med Chem59:5520-41 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase PAK 1
Name:Serine/threonine-protein kinase PAK 1
Synonyms:2.7.11.1 | Alpha-PAK | Cell division control protein 42 homolog | PAK 1/CDC42 | PAK-1 | PAK1 | PAK1_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | p21-activated kinase 1 | p65-PAK
Type:n/a
Mol. Mass.:60640.15
Organism:Homo sapiens (Human)
Description:Q13153
Residue:545
Sequence:
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP
GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN
PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDD
DDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTE
KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ
MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC
MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK
RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG
TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEA
TKNNH
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BDBM50182402
n/a
NameBDBM50182402
Synonyms:CHEMBL3819447
TypeSmall organic molecule
Emp. Form.C22H21ClN6O3
Mol. Mass.452.894
SMILESCNc1ncc2cc(-c3ccc(cc3Cl)-n3cncc(C)c3=O)c(=O)n(CCOC)c2n1
Structure
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