| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Fibroblast growth factor 2 |
|---|
| Ligand | BDBM50182286 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1584167 (CHEMBL3821485) |
|---|
| IC50 | 10000±n/a nM |
|---|
| Citation |  Castelli, R; Giacomini, A; Anselmi, M; Bozza, N; Vacondio, F; Rivara, S; Matarazzo, S; Presta, M; Mor, M; Ronca, R Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors. J Med Chem59:4651-63 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Fibroblast growth factor 2 |
|---|
| Name: | Fibroblast growth factor 2 |
|---|
| Synonyms: | Basic fibroblast growth factor | FGF-2 | FGF2 | FGF2_HUMAN | FGFB | Fibroblast growth factor 2 (bFGF) | Fibroblast growth factor receptor 2 (FGF-2) | HBGF-2 | Heparin-binding growth factor 2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 30803.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P09038 |
|---|
| Residue: | 288 |
|---|
| Sequence: | MVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPRRRPRRHPSVNPRSRAA
GSPRTRGRRTEERPSGSRLGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAA
PAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDG
RVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERL
ESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
|
|
|
|---|
| BDBM50182286 |
|---|
| n/a |
|---|
| Name | BDBM50182286 |
|---|
| Synonyms: | CHEMBL3819333 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H34F6O3 |
|---|
| Mol. Mass. | 484.5154 |
|---|
| SMILES | [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)C(O)CC(O)(C(F)(F)F)C(F)(F)F |r,t:9| |
|---|
| Structure | 
|
|---|
Search and Browse
