Reaction Details |
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Target | Platelet-activating factor acetylhydrolase |
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Ligand | BDBM50182419 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1584542 (CHEMBL3820397) |
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IC50 | 560±n/a nM |
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Citation | Woolford, AJ; Pero, JE; Aravapalli, S; Berdini, V; Coyle, JE; Day, PJ; Dodson, AM; Grondin, P; Holding, FP; Lee, LY; Li, P; Manas, ES; Marino, J; Martin, AC; McCleland, BW; McMenamin, RL; Murray, CW; Neipp, CE; Page, LW; Patel, VK; Potvain, F; Rich, S; Rivero, RA; Smith, K; Somers, DO; Trottet, L; Velagaleti, R; Williams, G; Xie, R Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening. J Med Chem59:5356-67 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Platelet-activating factor acetylhydrolase |
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Name: | Platelet-activating factor acetylhydrolase |
Synonyms: | 1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase |
Type: | PROTEIN |
Mol. Mass.: | 50084.41 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_156212 |
Residue: | 441 |
Sequence: | MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
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BDBM50182419 |
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n/a |
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Name | BDBM50182419 |
Synonyms: | CHEMBL3819444 |
Type | Small organic molecule |
Emp. Form. | C21H24N2O2S |
Mol. Mass. | 368.492 |
SMILES | COC(CO)Cc1csc(Nc2ccc(C)c(c2)-c2ccccc2C)n1 |
Structure |
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