Reaction Details | |||
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Target | Neurotensin receptor type 2 | ||
Ligand | BDBM50183343 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1586259 (CHEMBL3820077) | ||
EC50 | 345±n/a nM | ||
Citation | Narayanan, S; Maitra, R; Deschamps, JR; Bortoff, K; Thomas, JB; Zhang, Y; Warner, K; Vasukuttan, V; Decker, A; Runyon, SP Discovery of a novel small molecule agonist scaffold for the APJ receptor. Bioorg Med Chem24:3758-70 (2016) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Neurotensin receptor type 2 | |||
Name: | Neurotensin receptor type 2 | ||
Synonyms: | High-affinity levocabastine-sensitive neurotensin receptor | NT-R-2 | NTR2_RAT | Neurotensin receptor 2 | Neurotensin receptor type 2 | Ntr2 | Ntsr2 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 46280.50 | ||
Organism: | Rattus norvegicus | ||
Description: | ChEMBL_1466615 | ||
Residue: | 416 | ||
Sequence: |
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BDBM50183343 | |||
n/a | |||
Name | BDBM50183343 | ||
Synonyms: | CHEMBL3818506 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H30FN3O5 | ||
Mol. Mass. | 495.5426 | ||
SMILES | COc1cccc(OC)c1-c1cc(nn1-c1ccc(F)cc1)C(=O)N[C@H](CC(O)=O)C1CCCCC1 |r,wD:25.32,(2.66,2.78,;2.67,1.54,;1.33,.77,;,1.54,;-1.33,.77,;-1.33,-.77,;,-1.54,;-0,-3.08,;-1.07,-3.7,;1.33,-.77,;2.67,-1.54,;2.81,-3.06,;4.31,-3.38,;5.09,-2.05,;4.06,-.91,;4.37,.6,;3.31,1.71,;3.74,3.19,;5.24,3.56,;5.58,4.74,;6.3,2.44,;5.87,.96,;4.93,-4.79,;6.16,-4.92,;4.02,-6.03,;4.65,-7.44,;6.18,-7.61,;7.09,-6.36,;6.59,-5.24,;8.31,-6.49,;3.74,-8.69,;4.36,-10.1,;3.44,-11.34,;1.91,-11.17,;1.29,-9.76,;2.21,-8.52,)| | ||
Structure |