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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Apelin receptor | ||
| Ligand | BDBM50183341 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1586260 (CHEMBL3820078) | ||
| Ki | 1300±n/a nM | ||
| Citation |  Narayanan, S; Maitra, R; Deschamps, JR; Bortoff, K; Thomas, JB; Zhang, Y; Warner, K; Vasukuttan, V; Decker, A; Runyon, SP Discovery of a novel small molecule agonist scaffold for the APJ receptor. Bioorg Med Chem24:3758-70 (2016) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Apelin receptor | |||
| Name: | Apelin receptor | ||
| Synonyms: | AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11 | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 42664.06 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P35414 | ||
| Residue: | 380 | ||
| Sequence: |
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| BDBM50183341 | |||
| n/a | |||
| Name | BDBM50183341 | ||
| Synonyms: | CHEMBL3817879 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H34FN3O5 | ||
| Mol. Mass. | 523.5958 | ||
| SMILES | COc1cccc(OC)c1-c1cc(nn1-c1ccc(F)cc1)C(=O)N[C@@H](CCC1CCCCC1)CC(O)=O |r,wD:25.28,(2.66,2.78,;2.67,1.54,;1.33,.77,;,1.54,;-1.33,.77,;-1.33,-.77,;,-1.54,;-0,-3.08,;-1.07,-3.7,;1.33,-.77,;2.67,-1.54,;2.81,-3.06,;4.31,-3.38,;5.09,-2.05,;4.06,-.91,;4.37,.6,;3.31,1.71,;3.74,3.19,;5.24,3.56,;5.58,4.74,;6.3,2.44,;5.87,.96,;4.93,-4.79,;6.16,-4.92,;4.02,-6.03,;4.65,-7.44,;3.74,-8.69,;4.36,-10.1,;3.45,-11.34,;4.07,-12.75,;3.16,-13.99,;1.63,-13.82,;1.01,-12.41,;1.92,-11.17,;6.18,-7.61,;6.8,-9.02,;6.07,-10.02,;8.02,-9.16,)| | ||
| Structure | 
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