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TargetSerine/threonine-protein kinase RIPK2
LigandBDBM50184548
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1587102
IC50 50±n/a nM
Citation Haile PAVotta BJMarquis RWBury MJMehlmann JFSinghaus RCharnley AKLakdawala ASConvery MALipshutz DBDesai BMSwift BCapriotti CABerger SBMahajan MKReilly MARivera EJSun HHNagilla RBeal AMFinger JNCook MNKing BWOuellette MTTotoritis RDPierdomenico MNegroni AStronati LCucchiara SZiólkowski BVossenkämper AMacDonald TTGough PJBertin JCasillas LN The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase. J Med Chem 59:4867-80 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase RIPK2
Name:Serine/threonine-protein kinase RIPK2
Synonyms:Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:Protein
Mol. Mass.:61201.30
Organism:Homo sapiens (Human)
Description:n/a
Residue:540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
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  Blast E-value cutoff:
BDBM50184548
n/a
NameBDBM50184548
Synonyms:CHEMBL3822754
TypeSmall organic molecule
Emp. Form.C17H13FN4O2S
Mol. Mass.356.374
SMILESCS(=O)(=O)c1ccc2nccc(Nc3n[nH]c4ccc(F)cc34)c2c1
Structure
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