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TargetReceptor-interacting serine/threonine-protein kinase 2
LigandBDBM50184620
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1587102 (CHEMBL3825637)
IC50 630±n/a nM
Citation Haile, PAVotta, BJMarquis, RWBury, MJMehlmann, JFSinghaus, RCharnley, AKLakdawala, ASConvery, MALipshutz, DBDesai, BMSwift, BCapriotti, CABerger, SBMahajan, MKReilly, MARivera, EJSun, HHNagilla, RBeal, AMFinger, JNCook, MNKing, BWOuellette, MTTotoritis, RDPierdomenico, MNegroni, AStronati, LCucchiara, SZiólkowski, BVossenkämper, AMacDonald, TTGough, PJBertin, JCasillas, LN The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase. J Med Chem59:4867-80 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Receptor-interacting serine/threonine-protein kinase 2
Name:Receptor-interacting serine/threonine-protein kinase 2
Synonyms:CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:Protein
Mol. Mass.:61201.30
Organism:Homo sapiens (Human)
Description:n/a
Residue:540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
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  Blast E-value cutoff:
BDBM50184620
n/a
NameBDBM50184620
Synonyms:CHEMBL3822573
TypeSmall organic molecule
Emp. Form.C16H14N2O
Mol. Mass.250.2952
SMILESCc1ccc(O)cc1Nc1ccnc2ccccc12
Structure
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