Reaction Details |
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Target | Mitogen-activated protein kinase 14 |
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Ligand | BDBM50184548 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1587106 (CHEMBL3825641) |
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IC50 | >5000±n/a nM |
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Citation | Haile, PA; Votta, BJ; Marquis, RW; Bury, MJ; Mehlmann, JF; Singhaus, R; Charnley, AK; Lakdawala, AS; Convery, MA; Lipshutz, DB; Desai, BM; Swift, B; Capriotti, CA; Berger, SB; Mahajan, MK; Reilly, MA; Rivera, EJ; Sun, HH; Nagilla, R; Beal, AM; Finger, JN; Cook, MN; King, BW; Ouellette, MT; Totoritis, RD; Pierdomenico, M; Negroni, A; Stronati, L; Cucchiara, S; Ziólkowski, B; Vossenkämper, A; MacDonald, TT; Gough, PJ; Bertin, J; Casillas, LN The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase. J Med Chem59:4867-80 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 14 |
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Name: | Mitogen-activated protein kinase 14 |
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 41286.76 |
Organism: | Homo sapiens (Human) |
Description: | Q16539 |
Residue: | 360 |
Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50184548 |
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n/a |
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Name | BDBM50184548 |
Synonyms: | CHEMBL3822754 |
Type | Small organic molecule |
Emp. Form. | C17H13FN4O2S |
Mol. Mass. | 356.374 |
SMILES | CS(=O)(=O)c1ccc2nccc(Nc3n[nH]c4ccc(F)cc34)c2c1 |
Structure |
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