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TargetMitogen-activated protein kinase 14
LigandBDBM50184727
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1587106 (CHEMBL3825641)
IC50 1080±n/a nM
Citation Haile, PAVotta, BJMarquis, RWBury, MJMehlmann, JFSinghaus, RCharnley, AKLakdawala, ASConvery, MALipshutz, DBDesai, BMSwift, BCapriotti, CABerger, SBMahajan, MKReilly, MARivera, EJSun, HHNagilla, RBeal, AMFinger, JNCook, MNKing, BWOuellette, MTTotoritis, RDPierdomenico, MNegroni, AStronati, LCucchiara, SZiólkowski, BVossenkämper, AMacDonald, TTGough, PJBertin, JCasillas, LN The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase. J Med Chem59:4867-80 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50184727
n/a
NameBDBM50184727
Synonyms:CHEMBL3822938
TypeSmall organic molecule
Emp. Form.C17H13F3N2O
Mol. Mass.318.2931
SMILESCc1ccc(O)cc1Nc1ccnc2ccc(cc12)C(F)(F)F
Structure
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