| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 3 |
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| Ligand | BDBM50184765 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1587114 (CHEMBL3825649) |
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| IC50 | 16±n/a nM |
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| Citation |  Haile, PA; Votta, BJ; Marquis, RW; Bury, MJ; Mehlmann, JF; Singhaus, R; Charnley, AK; Lakdawala, AS; Convery, MA; Lipshutz, DB; Desai, BM; Swift, B; Capriotti, CA; Berger, SB; Mahajan, MK; Reilly, MA; Rivera, EJ; Sun, HH; Nagilla, R; Beal, AM; Finger, JN; Cook, MN; King, BW; Ouellette, MT; Totoritis, RD; Pierdomenico, M; Negroni, A; Stronati, L; Cucchiara, S; Ziólkowski, B; Vossenkämper, A; MacDonald, TT; Gough, PJ; Bertin, J; Casillas, LN The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase. J Med Chem59:4867-80 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 3 |
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| Name: | Receptor-interacting serine/threonine-protein kinase 3 |
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| Synonyms: | RIP-3 | RIP-like protein kinase 3 | RIP3 | RIPK3 | RIPK3_HUMAN | Receptor-interacting protein 3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56886.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_881455 |
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| Residue: | 518 |
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| Sequence: | MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE
VKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL
LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG
GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP
SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVST
VKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSS
VPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG
PRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLA
PSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
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| BDBM50184765 |
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| n/a |
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| Name | BDBM50184765 |
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| Synonyms: | CHEMBL3823499 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19FN4O2S |
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| Mol. Mass. | 398.454 |
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| SMILES | CC(C)(C)S(=O)(=O)c1ccc2nccc(Nc3n[nH]c4ccc(F)cc34)c2c1 |
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| Structure | 
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