| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 2 |
|---|
| Ligand | BDBM50184765 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1587116 (CHEMBL3825651) |
|---|
| IC50 | 2.0±n/a nM |
|---|
| Citation |  Haile, PA; Votta, BJ; Marquis, RW; Bury, MJ; Mehlmann, JF; Singhaus, R; Charnley, AK; Lakdawala, AS; Convery, MA; Lipshutz, DB; Desai, BM; Swift, B; Capriotti, CA; Berger, SB; Mahajan, MK; Reilly, MA; Rivera, EJ; Sun, HH; Nagilla, R; Beal, AM; Finger, JN; Cook, MN; King, BW; Ouellette, MT; Totoritis, RD; Pierdomenico, M; Negroni, A; Stronati, L; Cucchiara, S; Ziólkowski, B; Vossenkämper, A; MacDonald, TT; Gough, PJ; Bertin, J; Casillas, LN The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase. J Med Chem59:4867-80 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Receptor-interacting serine/threonine-protein kinase 2 |
|---|
| Name: | Receptor-interacting serine/threonine-protein kinase 2 |
|---|
| Synonyms: | Receptor-interacting serine/threonine-protein kinase 2 | Ripk2 | Tyrosine-protein kinase RIPK2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 60785.84 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_116814 |
|---|
| Residue: | 539 |
|---|
| Sequence: | MNGDAICSALPHIPYHKLADLHYLSRGASGTVSSARHADWRVRVAVKHLHIHTPLLDSER
NDILREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPEIAWPL
RFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
YKSAPEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVIMWEVLSRKQPFEEVTNPLQIMY
SVSQGHRPNTSEENLPFDIPHRGLMISLIQSGWAQNPDERPSFLKCLIELEPVLRTFEDI
TFLEAVIQLKKSKIQSASSTIHLCDKKMDLSLNIPASHPPQEESCGSSLLSRNAGSPGTS
RSLSAPQDKGFFHGGPQDCSSSKAYHCPGNHSWDGIISVSQEAAFCDRRASSCSLTVIRP
LLVEKSSERPQPGIAQQWIQSKREAIVSQMTEACLNQSLDALLSRDLIMKEDYELISTKP
TRTAKVRQLLDTSDIQGEEFARVIVQKLKDNKQMGLQPYPEVLLVSRTPSSNVLQNKTL
|
|
|
|---|
| BDBM50184765 |
|---|
| n/a |
|---|
| Name | BDBM50184765 |
|---|
| Synonyms: | CHEMBL3823499 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H19FN4O2S |
|---|
| Mol. Mass. | 398.454 |
|---|
| SMILES | CC(C)(C)S(=O)(=O)c1ccc2nccc(Nc3n[nH]c4ccc(F)cc34)c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
