| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Maternal embryonic leucine zipper kinase |
|---|
| Ligand | BDBM50185433 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1588031 (CHEMBL3824966) |
|---|
| IC50 | 2.0±n/a nM |
|---|
| Citation |  Touré, BB; Giraldes, J; Smith, T; Sprague, ER; Wang, Y; Mathieu, S; Chen, Z; Mishina, Y; Feng, Y; Yan-Neale, Y; Shakya, S; Chen, D; Meyer, M; Puleo, D; Brazell, JT; Straub, C; Sage, D; Wright, K; Yuan, Y; Chen, X; Duca, J; Kim, S; Tian, L; Martin, E; Hurov, K; Shao, W Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J Med Chem59:4711-23 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Maternal embryonic leucine zipper kinase |
|---|
| Name: | Maternal embryonic leucine zipper kinase |
|---|
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 74665.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q14680 |
|---|
| Residue: | 651 |
|---|
| Sequence: | MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
|
|
|
|---|
| BDBM50185433 |
|---|
| n/a |
|---|
| Name | BDBM50185433 |
|---|
| Synonyms: | CHEMBL3824068 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H32N6O |
|---|
| Mol. Mass. | 432.5612 |
|---|
| SMILES | CN1CCN(CC1)c1ccc(cc1)-n1cc(cn1)-c1ccncc1OCC1CCNCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
