| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PAK 1 |
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| Ligand | BDBM50185833 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1589061 (CHEMBL3824459) |
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| Ki | 18±n/a nM |
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| Citation |  Lee, W; Crawford, JJ; Aliagas, I; Murray, LJ; Tay, S; Wang, W; Heise, CE; Hoeflich, KP; La, H; Mathieu, S; Mintzer, R; Ramaswamy, S; Rouge, L; Rudolph, J Synthesis and evaluation of a series of 4-azaindole-containing p21-activated kinase-1 inhibitors. Bioorg Med Chem Lett26:3518-24 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PAK 1 |
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| Name: | Serine/threonine-protein kinase PAK 1 |
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| Synonyms: | 2.7.11.1 | Alpha-PAK | Cell division control protein 42 homolog | PAK 1/CDC42 | PAK-1 | PAK1 | PAK1_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | p21-activated kinase 1 | p65-PAK |
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| Type: | n/a |
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| Mol. Mass.: | 60640.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13153 |
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| Residue: | 545 |
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| Sequence: | MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP
GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN
PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDD
DDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTE
KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ
MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC
MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK
RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG
TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEA
TKNNH
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| BDBM50185833 |
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| n/a |
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| Name | BDBM50185833 |
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| Synonyms: | CHEMBL3823457 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N8 |
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| Mol. Mass. | 374.4423 |
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| SMILES | C[C@H](N(C)c1nccc(Nc2cc([nH]n2)C2CC2)n1)c1ccc2[nH]ccc2n1 |r| |
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| Structure | 
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