| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Estrogen receptor |
|---|
| Ligand | BDBM50186728 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1587749 (CHEMBL3825990) |
|---|
| IC50 | 436±n/a nM |
|---|
| Citation |  Kelly, PM; Bright, SA; Fayne, D; Pollock, JK; Zisterer, DM; Williams, DC; Meegan, MJ Synthesis, antiproliferative and pro-apoptotic activity of 2-phenylindoles. Bioorg Med Chem24:4075-4099 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Estrogen receptor |
|---|
| Name: | Estrogen receptor |
|---|
| Synonyms: | ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 66230.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P03372 |
|---|
| Residue: | 595 |
|---|
| Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
|
|
|
|---|
| BDBM50186728 |
|---|
| n/a |
|---|
| Name | BDBM50186728 |
|---|
| Synonyms: | CHEMBL3823426 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C34H32N2O4 |
|---|
| Mol. Mass. | 532.6289 |
|---|
| SMILES | Cc1c(-c2ccc(O)cc2)n(CCCCn2c(c(C)c3cc(O)ccc23)-c2ccc(O)cc2)c2ccc(O)cc12 |
|---|
| Structure | 
|
|---|
Search and Browse
