| Reaction Details |
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 | Report a problem with these data |
| Target | Cruzipain |
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| Ligand | BDBM50157741 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1590315 (CHEMBL3830354) |
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| IC50 | 400±n/a nM |
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| Citation |  Silva-Júnior, EF; Silva, EPS; França, PHB; Silva, JPN; Barreto, EO; Silva, EB; Ferreira, RS; Gatto, CC; Moreira, DRM; Siqueira-Neto, JL; Mendonça-Júnior, FJB; Lima, MCA; Bortoluzzi, JH; Scotti, MT; Scotti, L; Meneghetti, MR; Aquino, TM; Araújo-Júnior, JX Design, synthesis, molecular docking and biological evaluation of thiophen-2-iminothiazolidine derivatives for use against Trypanosoma cruzi. Bioorg Med Chem24:4228-4240 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cruzipain |
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| Name: | Cruzipain |
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| Synonyms: | CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase |
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| Type: | Protein |
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| Mol. Mass.: | 49831.41 |
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| Organism: | Trypanosoma cruzi |
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| Description: | P25779 |
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| Residue: | 467 |
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| Sequence: | MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLS
VFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEV
VGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK
TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVEL
PQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYW
IIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSY
FVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVR
SSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
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| BDBM50157741 |
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| n/a |
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| Name | BDBM50157741 |
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| Synonyms: | CHEMBL374508 | E-64 | E64 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H27N5O5 |
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| Mol. Mass. | 357.4054 |
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| SMILES | [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H]-1-[#8]-[#6@@H]-1-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r| |
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| Structure | 
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