Ki Summary

Reaction Details

Report a problem with these data

Target

Transient receptor potential cation channel subfamily V member 3

Ligand

BDBM50187699

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1589082 (CHEMBL3829467)

IC50

380±n/a nM

Citation

Gomtsyan, A; Schmidt, RG; Bayburt, EK; Gfesser, GA; Voight, EA; Daanen, JF; Schmidt, DL; Cowart, MD; Liu, H; Altenbach, RJ; Kort, ME; Clapham, B; Cox, PB; Shrestha, A; Henry, R; Whittern, DN; Reilly, RM; Puttfarcken, PS; Brederson, JD; Song, P; Li, B; Huang, SM; McDonald, HA; Neelands, TR; McGaraughty, SP; Gauvin, DM; Joshi, SK; Banfor, PN; Segreti, JA; Shebley, M; Faltynek, CR; Dart, MJ; Kym, PR Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists. J Med Chem59:4926-47 (2016) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Transient receptor potential cation channel subfamily V member 3

Name:

Transient receptor potential cation channel subfamily V member 3

Synonyms:

TRPV3 | TRPV3_HUMAN | Transient receptor potential cation channel subfamily V member 3 (TRPV3) | Vanilloid receptor-like 3

Type:

Enzyme

Mol. Mass.:

90635.51

Organism:

Homo sapiens (Human)

Description:

Q8NET8

Residue:

790

Sequence:

MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTS
PPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLK
KRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNIN
PNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGAD
VNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNIL
HALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYI
LSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEML
TLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMG
WLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLY
LFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLG
FGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLIT
YVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGEL
CKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFE
EVEEFPETSV

BDBM50187699

n/a

Name

BDBM50187699

Synonyms:

CHEMBL3828340

Type

Small organic molecule

Emp. Form.

C17H17F3N2O2

Mol. Mass.

338.3243

SMILES

C[C@@]1(O)C[C@](C1)([C@H](O)c1ccccn1)c1cc(ccn1)C(F)(F)F |r,wD:6.7,4.15,1.1,(.2,-3.5,;-.86,-4.12,;-.86,-5.35,;-2.35,-4.52,;-2.66,-3.08,;-1.26,-2.64,;-2.67,-1.54,;-3.73,-.93,;-1.33,-.77,;-1.33,.77,;,1.54,;1.33,.77,;1.33,-.77,;,-1.54,;-4,-3.86,;-4,-5.4,;-5.33,-6.17,;-6.66,-5.4,;-6.67,-3.86,;-5.33,-3.09,;-5.32,-7.71,;-4.26,-8.32,;-6.39,-8.33,;-5.32,-8.94,)|

Structure