Reaction Details |
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Target | Bromodomain-containing protein 1 |
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Ligand | BDBM50189403 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1589341 (CHEMBL3830585) |
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IC50 | 7943±n/a nM |
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Citation | Bamborough, P; Barnett, HA; Becher, I; Bird, MJ; Chung, CW; Craggs, PD; Demont, EH; Diallo, H; Fallon, DJ; Gordon, LJ; Grandi, P; Hobbs, CI; Hooper-Greenhill, E; Jones, EJ; Law, RP; Le Gall, A; Lugo, D; Michon, AM; Mitchell, DJ; Prinjha, RK; Sheppard, RJ; Watson, AJ; Watson, RJ GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain. ACS Med Chem Lett7:552-7 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bromodomain-containing protein 1 |
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Name: | Bromodomain-containing protein 1 |
Synonyms: | BR140-like protein | BRD1 | BRD1_HUMAN | BRL | BRL | BRPF2 | Bromodomain and PHD finger-containing protein 2 | Bromodomain-containing protein 1 |
Type: | PROTEIN |
Mol. Mass.: | 119557.65 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_105349 |
Residue: | 1058 |
Sequence: | MRRKGRCHRGSAARHPSSPCSVKHSPTRETLTYAQAQRMVEIEIEGRLHRISIFDPLEII
LEDDLTAQEMSECNSNKENSERPPVCLRTKRHKNNRVKKKNEALPSAHGTPASASALPEP
KVRIVEYSPPSAPRRPPVYYKFIEKSAEELDNEVEYDMDEEDYAWLEIVNEKRKGDCVPA
VSQSMFEFLMDRFEKESHCENQKQGEQQSLIDEDAVCCICMDGECQNSNVILFCDMCNLA
VHQECYGVPYIPEGQWLCRHCLQSRARPADCVLCPNKGGAFKKTDDDRWGHVVCALWIPE
VGFANTVFIEPIDGVRNIPPARWKLTCYLCKQKGVGACIQCHKANCYTAFHVTCAQKAGL
YMKMEPVKELTGGGTTFSVRKTAYCDVHTPPGCTRRPLNIYGDVEMKNGVCRKESSVKTV
RSTSKVRKKAKKAKKALAEPCAVLPTVCAPYIPPQRLNRIANQVAIQRKKQFVERAHSYW
LLKRLSRNGAPLLRRLQSSLQSQRSSQQRENDEEMKAAKEKLKYWQRLRHDLERARLLIE
LLRKREKLKREQVKVEQVAMELRLTPLTVLLRSVLDQLQDKDPARIFAQPVSLKEVPDYL
DHIKHPMDFATMRKRLEAQGYKNLHEFEEDFDLIIDNCMKYNARDTVFYRAAVRLRDQGG
VVLRQARREVDSIGLEEASGMHLPERPAAAPRRPFSWEDVDRLLDPANRAHLGLEEQLRE
LLDMLDLTCAMKSSGSRSKRAKLLKKEIALLRNKLSQQHSQPLPTGPGLEGFEEDGAALG
PEAGEEVLPRLETLLQPRKRSRSTCGDSEVEEESPGKRLDAGLTNGFGGARSEQEPGGGL
GRKATPRRRCASESSISSSNSPLCDSSFNAPKCGRGKPALVRRHTLEDRSELISCIENGN
YAKAARIAAEVGQSSMWISTDAAASVLEPLKVVWAKCSGYPSYPALIIDPKMPRVPGHHN
GVTIPAPPLDVLKIGEHMQTKSDEKLFLVLFFDNKRSWQWLPKSKMVPLGIDETIDKLKM
MEGRNSSIRKAVRIAFDRAMNHLSRVHGEPTSDLSDID
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BDBM50189403 |
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n/a |
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Name | BDBM50189403 |
Synonyms: | CHEMBL3828191 |
Type | Small organic molecule |
Emp. Form. | C22H27N5O3 |
Mol. Mass. | 409.4815 |
SMILES | COc1ccccc1C(=O)Nc1cc2n(C)c(=O)n(C)c2cc1N1CCNC[C@H]1C |r| |
Structure |
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