Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM19423 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1591084 (CHEMBL3828961) |
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IC50 | 1.000000±n/a nM |
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Citation | Wagner, FF; Weïwer, M; Steinbacher, S; Schomburg, A; Reinemer, P; Gale, JP; Campbell, AJ; Fisher, SL; Zhao, WN; Reis, SA; Hennig, KM; Thomas, M; Müller, P; Jefson, MR; Fass, DM; Haggarty, SJ; Zhang, YL; Holson, EB Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors. Bioorg Med Chem24:4008-4015 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM19423 |
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n/a |
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Name | BDBM19423 |
Synonyms: | HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophen-2-yl)phenyl]-4-acetamidobenzamide | N-[2-amino-5-(thiophen-2-yl)phenyl]-4-acetamidobenzamide (60) | SHI-1:2 | benzamide-type inhibitor, 19 |
Type | Small organic molecule |
Emp. Form. | C19H17N3O2S |
Mol. Mass. | 351.422 |
SMILES | CC(=O)Nc1ccc(cc1)C(=O)Nc1cc(ccc1N)-c1cccs1 |
Structure |
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