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TargetKelch-like ECH-associated protein 1
LigandBDBM50190587
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1589518 (CHEMBL3829092)
IC50 700±n/a nM
Citation Abdel-Magid, AF Therapeutic Potential for Modulation of Nrf2-Keap-1 Signaling Pathway as Treatment for Diabetes and Other Disorders. ACS Med Chem Lett7:660-1 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kelch-like ECH-associated protein 1
Name:Kelch-like ECH-associated protein 1
Synonyms:Cytosolic inhibitor of Nrf2 | INRF2 | KEAP1 | KEAP1/Cullin-3/Microtubule-associated protein tau | KEAP1_HUMAN | KIAA0132 | KLHL19 | Kelch-like protein 19
Type:PROTEIN
Mol. Mass.:69664.53
Organism:Homo sapiens (Human)
Description:ChEMBL_107924
Residue:624
Sequence:
MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
RSGVGVAVTMEPCRKQIDQQNCTC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50190587
n/a
NameBDBM50190587
Synonyms:CHEMBL3827496
TypeSmall organic molecule
Emp. Form.C24H27N3O4S
Mol. Mass.453.554
SMILESCc1cc(C)c(C)c(c1C)S(=O)(=O)Nc1ccc(N2CC[C@H](C2)C(O)=O)c2ncccc12 |r|
Structure
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