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TargetDihydrofolate reductase
LigandBDBM210928
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1589521 (CHEMBL3829095)
Ki 451±n/a nM
Citation Scocchera, EReeve, SMKeshipeddy, SLombardo, MNHajian, BSochia, AEAlverson, JBPriestley, NDAnderson, ACWright, DL Charged Nonclassical Antifolates with Activity Against Gram-Positive and Gram-Negative Pathogens. ACS Med Chem Lett7:692-6 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM210928
n/a
NameBDBM210928
Synonyms:UCP1164
TypeSmall organic molecule
Emp. Form.C24H24N4O3
Mol. Mass.416.4724
SMILESCCc1nc(N)nc(N)c1C#C[C@@H](C)c1cc(ccc1OC)-c1ccc(cc1)C(O)=O |r|
Structure
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