| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-[acyl-carrier-protein] reductase [NADH] |
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| Ligand | BDBM50191274 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1612658 (CHEMBL3854458) |
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| IC50 | 7690±n/a nM |
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| Citation |  Joshi, SD; Kumar, D; Dixit, SR; Tigadi, N; More, UA; Lherbet, C; Aminabhavi, TM; Yang, KS Synthesis, characterization and antitubercular activities of novel pyrrolyl hydrazones and their Cu-complexes. Eur J Med Chem121:21-39 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Enoyl-[acyl-carrier-protein] reductase [NADH] |
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| Name: | Enoyl-[acyl-carrier-protein] reductase [NADH] |
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| Synonyms: | Enoyl-ACP Reductase (InhA) | Enoyl-[acyl-carrier-protein] reductase | Enoyl-[acyl-carrier-protein] reductase [NADH] | INHA_MYCTU | NADH-dependent enoyl-ACP reductase | inhA |
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| Type: | Enzyme |
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| Mol. Mass.: | 28526.00 |
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| Organism: | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
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| Description: | P9WGR1 |
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| Residue: | 269 |
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| Sequence: | MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPL
LELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGI
HISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAG
KYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAK
TVCALLSDWLPATTGDIIYADGGAHTQLL
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| BDBM50191274 |
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| n/a |
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| Name | BDBM50191274 |
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| Synonyms: | CHEMBL3956359 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H21FN4O2 |
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| Mol. Mass. | 392.4261 |
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| SMILES | C\C(CCC(=O)Nc1ccc(F)cc1)=N/NC(=O)c1ccc(cc1)-n1cccc1 |
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| Structure | 
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