| Reaction Details |
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 | Report a problem with these data |
| Target | G protein-coupled receptor kinase 5 |
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| Ligand | BDBM50191311 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1612837 |
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| IC50 | 1600±n/a nM |
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| Citation |  Guccione, M; Ettari, R; Taliani, S; Da Settimo, F; Zappalą, M; Grasso, S G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives. J Med Chem59:9277-9294 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| G protein-coupled receptor kinase 5 |
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| Name: | G protein-coupled receptor kinase 5 |
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| Synonyms: | G protein-coupled receptor kinase GRK5 | GPRK5 | GRK5 | GRK5_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67798.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1280627 |
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| Residue: | 590 |
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| Sequence: | MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ
PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ
VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK
VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE
DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ
RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC
KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI
EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRN
HPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS
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| BDBM50191311 |
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| n/a |
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| Name | BDBM50191311 |
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| Synonyms: | CHEMBL3950887 |
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| Type | Small organic molecule |
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| Emp. Form. | C93H143N23O29 |
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| Mol. Mass. | 2047.2672 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)N)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r| |
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| Structure | 
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