| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-adrenergic receptor kinase 2 |
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| Ligand | BDBM50191313 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1612836 |
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| IC50 | 6100±n/a nM |
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| Citation |  Guccione, M; Ettari, R; Taliani, S; Da Settimo, F; Zappalą, M; Grasso, S G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives. J Med Chem59:9277-9294 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-adrenergic receptor kinase 2 |
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| Name: | Beta-adrenergic receptor kinase 2 |
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| Synonyms: | ADRBK2 | ARBK2_BOVIN | Beta-ARK-2 | Beta-adrenergic receptor kinase 2 | G-protein-coupled receptor kinase 3 | GRK3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 79815.63 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_113448 |
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| Residue: | 688 |
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| Sequence: | MADLEAVLADVSYLMAMEKSKATPAARASKKIVLPEPSIRSVMQKYLEERHEITFDKIFN
QRIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLENEEDRLCRSRQIYDTYIMKELLSC
SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGSIFQKFMESDKFTRFCQWKNV
ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE
IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE
VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMNVELPDVFSPE
LKSLLEGLLQRDVSKRLGCHGGSAQELKTHDFFRGIDWQHVYLQKYPPPLIPPRGEVNAA
DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVAETVYEAVNADTDKIEARK
RAKNKQLGHEEDYALGRDCIVHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQSL
LTMEQIVSVEETQIKDKKCILLRIKGGKQFVLQCESDPEFVQWKKELTETFMEAQRLLRR
APKFLNKSRSAVVELSKPPLCHRNSNGL
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| BDBM50191313 |
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| n/a |
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| Name | BDBM50191313 |
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| Synonyms: | CHEMBL3931500 |
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| Type | Small organic molecule |
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| Emp. Form. | C112H178N28O34 |
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| Mol. Mass. | 2460.7789 |
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| SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r| |
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| Structure | 
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