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TargetCoagulation factor III/Factor VIIa (fVIIa)
LigandBDBM50191346
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1612854
Ki 0.280000±n/a nM
Citation Zhang XGlunz PWJohnson JAJiang WJacutin-Porte SLadziata VZou YPhillips MSWurtz NRParkhurst BRendina ARHarper TMCheney DLLuettgen JMWong PCSeiffert DWexler RRPriestley ES Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa-Tissue Factor Complex. J Med Chem 59:7125-37 (2016) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor III/Factor VIIa (fVIIa)
Name:Coagulation factor III/Factor VIIa (fVIIa)
Synonyms:Coagulation factor III/VII | Coagulation factor VII/tissue factor
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of EBI is 69535
Components:This complex has 2 components.
Component 1
Name:Coagulation factor VII/tissue factor
Synonyms:CD_antigen=CD142 | Coagulation factor III | TF | Thromboplastin | Tissue factor
Type:PROTEIN
Mol. Mass.:33067.61
Organism:Homo sapiens (Human)
Description:ChEMBL_936735
Residue:295
Sequence:
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
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Component 2
Name:Thrombin and coagulation factor VII
Synonyms:Eptacog alfa | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | serum prothrombin conversion accelerator
Type:Enzyme
Mol. Mass.:51599.89
Organism:Homo sapiens (Human)
Description:n/a
Residue:466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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BDBM50191346
n/a
NameBDBM50191346
Synonyms:CHEMBL3978562
TypeSmall organic molecule
Emp. Form.C32H36N5O6P
Mol. Mass.617.6319
SMILESCCOP(O)(=O)c1ccc2NC(=O)OC[C@H](C)c3ccc(cc3C)[C@@H](Nc3ccc4c(N)nccc4c3)C(=O)N(C)Cc1c2 |r|
Structure
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