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TargetKallikrein-1
LigandBDBM189445
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1612859 (CHEMBL3854659)
Ki 270±n/a nM
Citation Zhang, XGlunz, PWJohnson, JAJiang, WJacutin-Porte, SLadziata, VZou, YPhillips, MSWurtz, NRParkhurst, BRendina, ARHarper, TMCheney, DLLuettgen, JMWong, PCSeiffert, DWexler, RRPriestley, ES Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa-Tissue Factor Complex. J Med Chem59:7125-37 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kallikrein-1
Name:Kallikrein-1
Synonyms:KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein
Type:Enzyme
Mol. Mass.:28874.69
Organism:Homo sapiens (Human)
Description:P06870
Residue:262
Sequence:
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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  Blast E-value cutoff:
BDBM189445
n/a
NameBDBM189445
Synonyms:US9174974, Example 31
TypeSmall organic molecule
Emp. Form.C33H35N5O5S
Mol. Mass.613.727
SMILESC[C@H]1COC(=O)Nc2ccc(c(CN(C)C(=O)[C@H](Nc3ccc4c(N)nccc4c3)c3ccc1c(C)c3)c2)S(=O)(=O)C1CC1 |r|
Structure
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