Reaction Details |
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Target | Coagulation factor IX |
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Ligand | BDBM189434 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1612867 (CHEMBL3854667) |
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Ki | 1600±n/a nM |
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Citation | Zhang, X; Glunz, PW; Johnson, JA; Jiang, W; Jacutin-Porte, S; Ladziata, V; Zou, Y; Phillips, MS; Wurtz, NR; Parkhurst, B; Rendina, AR; Harper, TM; Cheney, DL; Luettgen, JM; Wong, PC; Seiffert, D; Wexler, RR; Priestley, ES Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa-Tissue Factor Complex. J Med Chem59:7125-37 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor IX |
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Name: | Coagulation factor IX |
Synonyms: | Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component |
Type: | Enzyme |
Mol. Mass.: | 51768.83 |
Organism: | Homo sapiens (Human) |
Description: | P00740 |
Residue: | 461 |
Sequence: | MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
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BDBM189434 |
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n/a |
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Name | BDBM189434 |
Synonyms: | US9174974, Example 19 |
Type | Small organic molecule |
Emp. Form. | C33H34FN5O5S |
Mol. Mass. | 631.717 |
SMILES | C[C@H]1COC(=O)Nc2ccc(c(CN(C)C(=O)[C@H](Nc3ccc4c(N)ncc(F)c4c3)c3ccc1c(C)c3)c2)S(=O)(=O)C1CC1 |r| |
Structure |
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