| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 8 |
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| Ligand | BDBM50191771 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1613130 |
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| IC50 | 9.0±n/a nM |
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| Citation |  Glatthar R; Stojanovic A; Troxler T; Mattes H; Möbitz H; Beerli R; Blanz J; Gassmann E; Drückes P; Fendrich G; Gutmann S; Martiny-Baron G; Spence F; Hornfeld J; Peel JE; Sparrer H Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors. J Med Chem 59:7544-60 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase 8 |
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| Name: | Mitogen-activated protein kinase kinase kinase 8 |
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| Synonyms: | C-COT | COT proto-oncogene serine/threonine-protein kinase | Cancer Osaka thyroid oncogene | Mitogen-activated protein kinase kinase kinase 8 | Tpl-2 | Tumor Progression Loci-2 Kinase (COT) | Tumor progression locus 2 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 52916.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 467 |
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| Sequence: | MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERS
KSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGR
YQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE
IQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKG
LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL
CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPG
MRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELP
ENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
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| BDBM50191771 |
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| n/a |
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| Name | BDBM50191771 |
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| Synonyms: | CHEMBL3890505 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H26N8OS |
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| Mol. Mass. | 522.624 |
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| SMILES | CC(CN1CCOCC1)Nc1nc2ccc(cc2s1)-n1cnc2cnc3cnc(cc3c12)-c1ccncc1 |
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| Structure | 
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