| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor VII/Tissue factor |
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| Ligand | BDBM50192767 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1613695 (CHEMBL3855495) |
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| Ki | 0.220000±n/a nM |
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| Citation |  Ladziata, VU; Glunz, PW; Zou, Y; Zhang, X; Jiang, W; Jacutin-Porte, S; Cheney, DL; Wei, A; Luettgen, JM; Harper, TM; Wong, PC; Seiffert, D; Wexler, RR; Priestley, ES Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors. Bioorg Med Chem Lett26:5051-5057 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor VII/Tissue factor |
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| Name: | Coagulation factor VII/Tissue factor |
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| Synonyms: | Coagulation factor III/Factor VIIa (fVIIa) | Coagulation factor III/VII |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of EBI is 69535 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Tissue factor |
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| Synonyms: | CD_antigen=CD142 | Coagulation factor III | Coagulation factor VII/tissue factor | F3 | TF | TF_HUMAN | Thromboplastin | Tissue factor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33067.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_936735 |
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| Residue: | 295 |
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| Sequence: | METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
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| Component 2 |
| Name: | Coagulation factor VII |
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| Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
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| Type: | Enzyme |
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| Mol. Mass.: | 51599.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 466 |
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| Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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| BDBM50192767 |
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| n/a |
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| Name | BDBM50192767 |
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| Synonyms: | CHEMBL3984725 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H38FN5O5 |
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| Mol. Mass. | 639.7158 |
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| SMILES | C[C@H]1COC(=O)Nc2ccc(c(CN(C)C(=O)[C@H](Nc3ccc4c(N)ncc(F)c4c3)c3ccc1c(C)c3)c2)C1(CCCC1)C(O)=O |r| |
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| Structure | 
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