Reaction Details |
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Target | E3 ubiquitin-protein ligase SMURF1 |
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Ligand | BDBM50193010 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1614090 |
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IC50 | 1.4±n/a nM |
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Citation | Abdel-Magid, AF Therapeutic Potential of Smurf-1 Inhibitors for the Treatment of Pulmonary Arterial Hypertension (PAH). ACS Med Chem Lett7:878-880 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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E3 ubiquitin-protein ligase SMURF1 |
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Name: | E3 ubiquitin-protein ligase SMURF1 |
Synonyms: | E3 ubiquitin-protein ligase SMURF1 | HECT-type E3 ubiquitin transferase SMURF1 | KIAA1625 | SMAD ubiquitination regulatory factor 1 | SMAD-specific E3 ubiquitin-protein ligase 1 | SMUF1_HUMAN | SMURF1 | hSMURF1 |
Type: | PROTEIN |
Mol. Mass.: | 86120.64 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_116984 |
Residue: | 757 |
Sequence: | MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP
KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK
LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA
PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY
EQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSV
NCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPS
EGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMR
PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS
INPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLV
WILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI
EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVR
WFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLP
KAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
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BDBM50193010 |
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n/a |
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Name | BDBM50193010 |
Synonyms: | CHEMBL3949800 |
Type | Small organic molecule |
Emp. Form. | C22H32N4O4 |
Mol. Mass. | 416.5139 |
SMILES | CC1CCC(OC1)c1onc(C(O)=Nc2c(C)n(C)n(C3CCCCC3)c2=O)c1C |
Structure |
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