Ki Summary

Reaction Details

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Target

NAD-dependent histone deacetylase SIR2

Ligand

BDBM50156760

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1614264 (CHEMBL3856333)

IC50

68000±n/a nM

Citation

Kumar, A; Chauhan, S How much successful are the medicinal chemists in modulation of SIRT1: A critical review. Eur J Med Chem119:45-69 (2016) [PubMed] Article

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Get all data from this article, Assay Method

NAD-dependent histone deacetylase SIR2

Name:

NAD-dependent histone deacetylase SIR2

Synonyms:

MAR1 | SIR2 | SIR2_YEAST

Type:

PROTEIN

Mol. Mass.:

63277.80

Organism:

Saccharomyces cerevisiae

Description:

ChEMBL_942450

Residue:

562

Sequence:

MTIPHMKYAVSKTSENKVSNTVSPTQDKDAIRKQPDDIINNDEPSHKKIKVAQPDSLRET
NTTDPLGHTKAALGEVASMELKPTNDMDPLAVSAASVVSMSNDVLKPETPKGPIIISKNP
SNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQAL
IGTINSIVHINSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSN
FFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNI
FMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKL
VQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAAS
QGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVS
EIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKN
FKCQEKDKGVYVVTSDEHPKTL

BDBM50156760

n/a

Name

BDBM50156760

Synonyms:

(E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide | 2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide | 2-{[(1-(2-hydroxy-naphthalen-1-yl)meth-(E)-ylidene]amino}-N-(1-phenylethyl)-benzamide | 2-{[1-(2-hydroxynaphthalen-1-yl)meth-(E)-ylene]amino}-N-(1-phenylethyl)benzamide | CHEMBL380797 | Sirtinol

Type

Small organic molecule

Emp. Form.

C26H22N2O2

Mol. Mass.

394.4651

SMILES

CC(NC(=O)c1ccccc1\N=C\c1c(O)ccc2ccccc12)c1ccccc1

Structure