| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 5 activator 1 |
|---|
| Ligand | BDBM50193085 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1614404 (CHEMBL3856473) |
|---|
| IC50 | <10.0±n/a nM |
|---|
| Citation |  Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy. J Med Chem59:8667-8684 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 5 activator 1 |
|---|
| Name: | Cyclin-dependent kinase 5 activator 1 |
|---|
| Synonyms: | CDK5/p35 | Cyclin-Dependent Kinase 5 (CDK5) | Cyclin-dependent kinase 5 regulatory subunit 1 | Cyclin-dependent kinase 5/CDK5 activator 1 |
|---|
| Type: | Protein Complex |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Cyclin-dependent kinase 5 |
|---|
| Synonyms: | CDK5 | CDK5_HUMAN | CDKN5 | Cell division protein kinase 5 | Cyclin-dependent kinase 5 (CDK5/ p25) | Cyclin-dependent kinase 5 (CDK5/p35) | Cyclin-dependent-like kinase 5 | Cyclin-dependent-like kinase 5 (CDK5) | PSSALRE | Serine/threonine-protein kinase PSSALRE | Tau protein kinase II catalytic subunit |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 33308.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 292 |
|---|
| Sequence: | MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH
KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR
NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS
TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYP
MYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCPP
|
|
|
|---|
| Component 2 |
| Name: | Cyclin-dependent kinase 5 activator 1 |
|---|
| Synonyms: | CD5R1_HUMAN | CDK5R | CDK5R1 | Cyclin-Dependent Kinase 5 Activator 1, p35 | Cyclin-dependent kinase 5 (CDK5/p25) | Cyclin-dependent kinase 5 regulatory subunit 1 | NCK5A | TPKII regulatory subunit | p35 |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 34077.43 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q15078 |
|---|
| Residue: | 307 |
|---|
| Sequence: | MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSA
KKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTG
GSSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRS
VDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNE
ISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKR
LLLGLDR
|
|
|
|---|
| BDBM50193085 |
|---|
| n/a |
|---|
| Name | BDBM50193085 |
|---|
| Synonyms: | CHEMBL3925525 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H21F3N4O3S |
|---|
| Mol. Mass. | 430.445 |
|---|
| SMILES | C[C@H](O)[C@@H](C)Oc1nc(Nc2ccc(cc2)S(=N)(=O)C2CC2)ncc1C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
