Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1
LigandBDBM50110183
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1614423 (CHEMBL3856492)
Ki 10.0±n/a nM
Citation Sonawane, YATaylor, MANapoleon, JVRana, SContreras, JINatarajan, A Cyclin Dependent Kinase 9 Inhibitors for Cancer Therapy. J Med Chem59:8667-8684 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
Name:Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
Synonyms:CDK6/cyclin D1 | Cyclin-dependent kinase 6/G1/S-specific cyclin D1
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 1935149
Components:This complex has 2 components.
Component 1
Name:G1/S-specific cyclin-D1
Synonyms:B-cell lymphoma 1 protein | BCL-1 | BCL-1 oncogene | BCL1 | CCND1 | CCND1_HUMAN | PRAD1 | PRAD1 oncogene
Type:Enzyme Subunit
Mol. Mass.:33717.70
Organism:Homo sapiens (Human)
Description:n/a
Residue:295
Sequence:
MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRK
HAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:Cyclin-dependent kinase 6
Synonyms:CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:Enzyme Subunit
Mol. Mass.:36937.42
Organism:Homo sapiens (Human)
Description:Q00534
Residue:326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50110183
n/a
NameBDBM50110183
Synonyms:Abemaciclib | LY-2835219 | US10626107, Example LY2835219 | US10662186, Compound LY2835219 | US10696678, Example LY2835219 | US10988476, Compound LY2835219 | US11053238, LY2835219 | US11091476, Example LY2835219 | US11351170, Example Abemaciclib
TypeSmall organic molecule
Emp. Form.C27H32F2N8
Mol. Mass.506.5934
SMILESCCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: