Citation | Kung, PP; Rui, E; Bergqvist, S; Bingham, P; Braganza, J; Collins, M; Cui, M; Diehl, W; Dinh, D; Fan, C; Fantin, VR; Gukasyan, HJ; Hu, W; Huang, B; Kephart, S; Krivacic, C; Kumpf, RA; Li, G; Maegley, KA; McAlpine, I; Nguyen, L; Ninkovic, S; Ornelas, M; Ryskin, M; Scales, S; Sutton, S; Tatlock, J; Verhelle, D; Wang, F; Wells, P; Wythes, M; Yamazaki, S; Yip, B; Yu, X; Zehnder, L; Zhang, WG; Rollins, RA; Edwards, M Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors. J Med Chem59:8306-25 (2016) [PubMed] Article |
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SMILES | Cc1noc(C)c1-c1ccc2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl |(62.09,-40.24,;61.77,-41.75,;62.8,-42.89,;62.03,-44.22,;60.52,-43.9,;59.38,-44.93,;60.36,-42.37,;59.02,-41.6,;57.69,-42.37,;56.37,-41.6,;56.38,-40.08,;55.05,-39.32,;55.05,-37.78,;56.38,-37,;56.38,-35.46,;55.04,-34.69,;55.05,-33.15,;56.38,-32.38,;53.72,-32.38,;52.38,-33.14,;51.05,-32.37,;52.38,-34.68,;53.71,-35.46,;53.71,-37,;57.7,-37.78,;59.04,-37.01,;57.7,-39.32,;59.02,-40.08,;60.35,-39.31,)| |