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TargetProstaglandin E synthase
LigandBDBM50194193
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1616434 (CHEMBL3858503)
IC50 6.0±n/a nM
Citation Kuklish, SLAntonysamy, SBhattachar, SNChandrasekhar, SFisher, MJFretland, AJGooding, KHarvey, AHughes, NELuz, JGManninen, PRMcGee, JENavarro, ANorman, BHPartridge, KMQuimby, SJSchiffler, MASloan, AVWarshawsky, AMYork, JSYu, XP Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors. Bioorg Med Chem Lett26:4824-4828 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E synthase
Name:Prostaglandin E synthase
Synonyms:MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:Protein
Mol. Mass.:17112.22
Organism:Homo sapiens (Human)
Description:n/a
Residue:152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
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  Blast E-value cutoff:
BDBM50194193
n/a
NameBDBM50194193
Synonyms:CHEMBL3926051
TypeSmall organic molecule
Emp. Form.C22H29N3O2
Mol. Mass.367.4846
SMILESCc1cccc2ccc(nc12)N1CC[C@H](C(=O)N[C@H]2CCOC2)C(C)(C)C1 |r|
Structure
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